Alzheimer’s Disease (AD): High cholesterol is associated with lower Mini‐Mental State Exam (MMSE) scores

Background Alzheimer’s Disease (AD) is the leading cause of dementia in elderly. The epsilon 4 allele apolipoprotein E gene that encodes major brain lipid carrier and metabolic disorders, such as obesity type 2 diabetes, were identified AD risk factors, suggesting abnormal metabolism could influence progression disease. Additionally, lowering cholesterol associated with reduced central nervous system (CNS) amyloid deposition increased dietary increases accumulation animal studies. Method 154 outpatients diagnosis conforming to criteria proposed by NINCDS-ADRDA (2011), followed-up at a public university hospital, had their levels assessed MMSE scores evaluated. Results 90 patients (58,44%) presented high (total level ≥ 190 mg/dL and/or LDL 130 mg/dL) 64 (41,56%) normal range < mg/d L mg/dL). From group, 10 (11,11%) severe cognitive impairment (MMSE 10), 50 (55,55%) moderate = – 20) 30 (33,34%) mild > 20). 5 (7,81%) impairment, 19 (29,69%) 40 (62,5%) impairment. Both groups, range, on average same educational level: 2,91 3,42 years, respectively. Conclusion In this sample AD, lower when compared range.